Jennifer H. Shaw, Assistant ProfessorIntercellular signaling in the vessel wall, angiogenesis & arteriogenesis, oxidative stress
Ph.D., 2000, University of Montana
Lab website: http://jenniferhshaw.wix.com/the-shaw-lab
Our lab is interested in intercellular signaling within the blood vessel wall that affects angiogenesis (the growth of new blood vessels) and arteriogenesis (the expansion of pre-existing collateral vessels), particularly in the context of vascular disease. We strive to gain a better understanding of how signaling molecules such as hydrogen peroxide and hydrogen sulfide regulate these compensatory processes. We study human coronary vascular cells in culture and, along with our collaborators, are developing a unique fish model system to study hydrogen sulfide homeostasis for application in human vascular and metabolic disease.
- Tobler M, Henpita C, Bassett B, Kelley J, Shaw JH. H2S exposure elicits differential expression of candidate genes in fish adapted to sulfidic and non-sulfidic environments. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology (2014) doi: 10.1016/j.cbpa.2014.04.012.
- Xiang L, Varshney R, Rashdan N, Shaw JH, Lloyd PG. Placenta growth factor and vascular endothelial growth factor-A have differential, cell-type specific patterns of expression in vascular cells. Microcirculation (2014) doi: 10.1111/micc.12113.
- Shaw JH, Lloyd PG. Post-transcriptional regulation of placenta growth factor mRNA by hydrogen peroxide. Microvascular Research 84 (2012) 155-160.
- Shaw JH, Xiang L, Shah A, and Lloyd PG. Placental growth factor expression is regulated by hydrogen peroxide in vascular smooth muscle cells. American Journal of Physiology 2011 Feb; 300(2):C349-55.
- Shaw J, Grund V, Durling L, Crane D, Caldwell HD. Infect Immun. 2002 Mar: 70(3): 1097-105. Dendritic cells pulsed with a recombinant chlamydial major outer membrane protein antigen elicit a CD4(+) type 2 rather than type 1 immune response that is not protective.
- Shaw JH, Grund VR, Durling L, Caldwell HD. Infect Immuno. 2001 Jul: 69(7):4667-72. Expression of genes encoding Th1 cell-activating cytokines and lymphoid homing chemokines by chlamydia-pulsed dendritic cells correlates with protective immunizing efficacy.