Matteo Minghetti, Assistant Professor
Metal homeostasis, Fish Physiology, Cell Biology, Molecular Ecotoxicology
Ph.D., 2009, University of Stirling, UK
Office: LSW 411/429
I am interested in the role of metals in biology and toxicology. Essential metals like iron, zinc and copper are required by all organisms to thrive. However, the same properties that make these metals necessary for life also make them extremely toxic. Therefore, organisms have evolved systems to handle metals thus avoiding dangerous and wasteful nonspecific interactions. Several proteins are involved in the tight regulation of intracellular metal concentration and distribution that is defined as metal homeostasis. The study of this sophisticated machinery at the molecular level will ultimately help us understand how organisms acclimate and adapt to multiple environmental stressors including metals. This research uses fish and in vitro models of epithelial barriers (i.e. fish gill and gut). Methods applied span from analytical chemistry to molecular biology and cellular imaging.
- Ibrahim, M., Oldham, D., Minghetti, M. 2020. Role of metal speciation in the exposure medium on the toxicity, bioavailability and bio-reactivity of copper, silver, cadmium and zinc in the rainbow trout gut cell line (RTgutGC). Comp. Biochem. Physiol. Part - C Toxicol. Pharmacol. 236, 108816.
- Minghetti, M., Dudefoi, W., Quing, M., Catalano, J.G. 2019. Environmental Science Nano Emerging investigator series : linking chemical transformations of silver and silver nanoparticles to their bio-reactivity. Environ. Sci. Nano, 6, 2948.
- Minghetti, M., Schirmer, K. 2019. Interference of silver nanoparticles with essential metal homeostasis in a novel enterohepatic fish in vitro system. Environ. Sci. Nano 6, 1777–1790.
- Minghetti, M., Drieschner, C., Bramaz, N., Schug, H., Schirmer, K. 2017. A fish intestinal epithelial barrier model established from the rainbow trout (Oncorhynchus mykiss) cell line, RTgutGC. Cell Biol. Toxicol. 33, 539–555.
- Minghetti, M., Schirmer, K. 2016. Effect of media composition on bioavailability and toxicity of silver and silver nanoparticles in fish intestinal cells (RTgutGC). Nanotoxicology 10, 1526–1534.
- Minghetti, M., Schnell, S., Chadwick, M.A., Hogstrand, C., Bury, N.R. 2014. A primary FIsh Gill Cell System (FIGCS) for environmental monitoring of river waters. Aquat. Toxicol. 154, 184–192.
- Behra, R., Sigg, L., Clift, M.J.D., Herzog, F., Minghetti, M., Johnston, B., Petri-Fink, A., Rothen-Rutishauser, B., Rothen-Rutishauser, B. 2013. Bioavailability of silver nanoparticles and ions : from a chemical and biochemical perspective. J. R. Soc. Interface 10, 20130396.
- Minghetti, M., Leaver, M.J., George, S.G. 2010. Multiple Cu ATPase genes are differentially expressed and transcriptionally regulated by Cu exposure in sea bream, Sparus aurata. Aquat. Toxicol. 97, 23–33.
- Minghetti, M., Leaver, M.J.J., Carpenè, E., George, S.G.G., Carpene, E., George, S.G.G. 2008. Copper transporter 1, metallothionein and glutathione reductase genes are differentially expressed in tissues of sea bream (Sparus aurata) after exposure to dietary or waterborne copper. Comp. Biochem. Physiol. Part C Toxicol. Pharmacol. 147, 450–459.